Jobs
Statistical Geneticist at 54gene
54gene was founded in 2019 by Dr. Abasi Ene-Obong to address the significant gap in the global genomics market; Nearly 90% of genetic material used in pharmaceutical research is Caucasian. Only 2% is African, despite the fact that Africans and people of African ancestry are more genetically diverse than all other world populations combined.
We are recruiting to fill the position below:
Job Title: Statistical Geneticist
Location: Lagos
Department: Data/Scientific Team
Status: Full-Time, Exempt
Reports to: Chief Data/ Scientific Officer
Job Description
- The Statistical Geneticist will have an opportunity to make his or her mark within a growing scientific team within 54gene.
- S/he will support the research discovery and development activities to transform human genetics and genomics discoveries to therapeutic hypotheses, and effectively communicate results to impact our emerging pipeline.
- The successful candidate will have the opportunity to work in a fast-paced and highly collaborative environment and will be responsible for developing and employing rigorous statistical and computational approaches.
- S/he will demonstrate experience in genotype-phenotype associations as well as engage fellow scientists and project teams to leverage genomics data in achieving project objectives.
Roles and Responsibilities
- Apply and develop robust statistical and computational approaches to analyze whole-exome and whole-genome sequence data in combination with phenotypic or other genomic data to enable disease/target/biomarker identification and evaluation, exploring mechanism of action, and identification of genetic causal links to disease or subtypes of disease
- Evaluate and implement statistical methods to integrate, summarize and report genetic, genomic, and other omics data, examples include WGS, WES, GWAS, and RNA-seq
- Understand strategies and methods for genotype imputation, haplotyping, relationship inference and/or polygenic risk score estimation
- Work collaboratively within a diverse team, and provide learning opportunities for other staff, if and when applicable
Qualifications
Knowledge, Skills & Abilities:
- Knowledge of genome-wide analyses and approaches, including quality control options for genomic data, approaches for association analysis in the presence of relatedness or population structure, and approaches for burden-based analyses
- Ability to learn in a fast-paced work environment
- Ability to coordinate and manage tasks and processes with minimal supervision
- Strong sense of responsibility with keen attention to details
- Good communication skills
- Expertise with modern cluster and cloud computing environments and with statistical analysis software (R environment for statistical computing, STATA) and human genetics analysis tools (METAL, GCTA, PLINK or similar)
Education & Certifications:
- M.S or PhD in Biostatistics, Statistical Genetics, Computational Biology, or related field
- 3+ years’ experience in biostatistics or statistical analysis of DNA sequencing data
Experience:
- Knowledge and expertise with whole genome as well as whole exome sequence analysis
- Solid foundation in statistical genetics principles and applications, especially population genetics
- Demonstrated experience in statistical programming using R and other programming languages (e.g. Python, C/C++, Javascript) on large datasets
- Ability to annotate and explore potential functions of identified variants with publicly available functional datasets or fine-mapping tools
- Knowledge of rare variant validation using multiple technologies and publicly available resources
- Experience in genome-wide (GWAS) and phenome-wide association studies, especially as they relate to implications in large multi-ethnic cohorts and analysis
- Experience designing and analyzing validation experiments for laboratory assays
- Effective at communicating insights and presenting concepts to a diverse audience
- Ability to work with multidisciplinary teams; Experience collaborating with lab scientists on data generation and analysis
Other:
- Authorization to work in the Nigeria, the United States, and/or the United Kingdom
- Must live in one of the locations listed above
- Valid international travel documentation
- Occasional domestic and international travel may be required
